Anemia Classification

IDA ( Iron Deficiency Anemia )

  • 1 ml of RBC == 1 mg of Fe
  • Ferritin ↓– storage Iron along with hemosiderin . This is a complex of ferric salt and apoferritin ,protein . differentiates it from ACD,thallasemia,Sideroblastic
  • transferrin –  transport protein = TIBC ↑
  • characterized by hypochromic, microcytic anemia
  • MCV ↓ , HCT & HgB ↓

Megaloblastic Anemia

  • Macrocytic
  • MCV ↑
  • B12 and Folic deficiency
  • Pernicious Anemia – failure of the gastric mucosa to secrete intrinsic factor  

 

Anemia of Chronic Diseases(ACD)

  • Normocytic,normochromic  although 20 – 50 % would be microcytic hypochromic
  • SI ↓, TIBC normal/↓ ,Ferritin ↑

 

Sideroblastic Anemia

  • Hypochromic, often microcytic mixed with normochromic = dimorphic
  • SI ↑, TIBC ↓, % SAT ↑↑
  • ring sideroblasts” in marrow

 

Blood Loss Anemia

  • Acute – normocytic, normochromic
  • Chronic – microcytic then hypochromic

 

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Macrocytic Anemia(Increased MCV)

normochromic base on the film and by the MCHC

  • Megaloblastic
  • Non-Megaloblastic
Microcytic and Hypochromic Anemias(Decreased MCV and MCH)

MCHC = normal

  • IDA
  • ACD
  • Thallasemia
  • Sideroblastic
Normocytic and Normochromic Anemia(Normal MCV)

check Reticulocyte production index and Bone marrow

DAT

hemolytic anemias

 

SOURCE:

Source:

Henry’s Clinical Diagnosis and Management by Laboratory Methods 21 edition

Chapter 31

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